Molecular and metabolic mechanisms of type 1 and type 2 diabetes mellitus, laboratory diagnostics

Diabetes mellitus is a widespread disease in the world, despite advances understanding molecular mechanisms of development multifactorial processes associated with this nosology. The review material devoted to modern ideas about immunogenetic causes diabetes, changes metabolism violation carbohydrate metabolism, types and principles laboratory diagnostics accordance WHO criteria. Information on functional insulin deficiency presented. biochemical aspects hyperglycemia as main mechanism organ tissue damage resulting from protein glycosylation are considered. article describes metabolic pathways disorders carbohydrate, lipid, protein, water-salt leading occurrence glucosuria, polyuria, polydipsia, ketonuria, ketoacidosis other complications diabetes mellitus. Knowledge concept various forms point view biochemistry pathogenesis, medicine will be useful for doctors all specialties clinical diagnostics.